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Grey’s Anatomy opens up very similar to the way it opened up the first season. Everyone except for George. They all get new interns and Christina gets Meredith’s half sister Lexie. Lexie tries to meet Meredith not knowing who she is.

Izzie bumps into George and asks him why he’s been ignoring her, she told him she loved him and it’s been 17 days with out a word from him. He just tells her how he’s been busy and has things on his mind. He didn’t pass the interns exam remember?! He then walks away. Izzie’s interns all whisper behind her back, but she can here them bickering on about how they got the dud doctor, did you hear that last year she lost a patient and then got suspended?!

Derek goes around trying to find a friend to hang out with. He asks Bailey if she wants to go for a drink after work, and she tells him no, just because Addison left, and Burk left, and he’s not friends with Mark so just because he doesn’t have friends doesn’t mean they can hang out now. Derek says I have friends, and looks around to find the Chief, he says I have the Chief and walks away. He goes to the Chief and asks if he wants to have a drink after work, he says he can’t because he’s busy. He tells Derek how his wife hasn’t let him move back in, but they are trying to work things out. Mark walks up and says I’ll have a drink with you. The Chief thinks it’s a good idea, but Derek says no one said anything about a drink and walks away.

Victim’s from an accident come in and they all go rushing outside with their interns. Lexie starts to ask George who is Meredith? He asks why, and she says because I’m Lexie Grey, he says I know who you are. Before anything else is said, they tell Meredith to grab that victim. For the first time Lexie sees who her half sister is. Meredith gets a victim who is pregnant and has just lost her arm. She goes to rush inside and Lexie stops her to tell her that she is her half sister Lexie. Meredith just looks at her and keeps going.

Christina and Meredith talk about how they haven’t seen Derek or Burk. But they are just fine.

Alex is in the surgery with Dr. Bailey when Callie comes in looking for him. She gets upset that why wasn’t she paged if this is her patient. Before Alex is able to say anything, Dr. Bailey interrupts and says because this patient needed emergency surgery and he did what he had to do to save his life. Callie stays quiet and tells Alex that she wants all the paper work on her desk later and walks out.

Callie is having a hard time becoming Chief Resident. No one wants to listen to her especially Dr. Bailey who is still upset she wasn’t chosen for Chief Resident. The Chief tries to talk to Bailey but she keeps pushing him away and telling him she has nothing to talk to him about. Eventually the Chief gets into the surgery room with Bailey and tells her he didn’t choose her because she belongs in the surgery room, not behind a desk telling people what to do. She’ll thank him one day.

Meredith and Derek finally run into each other, He asks how she is doing and she says fine. He says isn’t she always? She asks if he’s seen a missing arm of her patient and he tells her no. Lexie walks up at this point and Derek looks at her and says you are the girl from the bar? Meredith turns to him and says’ “I’m the girl from the bar” and walks away. Lexie tells Derek that she is Meredith’s half sister and Meredith hates her already. Derek looks shocked, and Lexie just tells him that she came looking for him, he’s needed in the emergency room. Christina’s patient is unable to move, the only thing holding his head is skin and muscle tissue. They need to operate as soon as possible. They bring his family in and it’s a tear filling moment as the Wife tells him to pull through, in the back stand his two children. He blinks one time for No and two times for Yes but this time he blinked three times. They wonder what it means and the wife says does that mean I LOVE YOU? He blinks two times for Yes. She starts to cry as the children are crying in the back as well. Right before they take him into surgery the daughter comes up to him real quick and does three blinks. And they take him off to surgery.

Derek sees Cristina and asks if she wants to go for a drink after work. She says no I don’t like you. He says why because of Meredith? She no because I just don’t like you. Derek asks how Meredith is doing and she says fine. He says yes that’s the problem she is always fine. Cristina tells him that they are just women who are always fine. She then asks him where Burk is, does he have the day off? Derek is forced to tell her the truth. He tells her that Burk gave in his resignation two weeks ago. Is she okay? She says she is fine. He says of course you are, and walks away.

Meredith is in surgery with Mark and George and the patient begins to go into Labor. George rushes in and delivers the baby. Lexie goes to congratulate him and asks him why he isn’t happy. He says because this isn’t his first surgery it’s like dajavu, this is his second year as an intern.

Derek bumps into Mark again and Mark tells him that he wants to go get a drink with him. Derek says why because Addison isn’t here anymore? He says no, he didn’t come here for Addison or for this position he came here for him. He then realizes what he said didn’t sound right, and starts to laugh, he says I can’t take that back now huh? Derek tells him no. He says so how about that drink. Derek smiles and says maybe another time and walks away.

Meredith is getting ready to leave when Lexie calls out her name, at the same time Derek calls her name and she stands there in the middle looking to which way to go, with out saying anything she turns to Derek and walks away.

George walks into the locker room and everyone is staring, he snaps and asks what is it? And they all start clapping, asking how does he feel about delivering his first baby on his “First” day as an intern. Lexie says yes how does it feel on your first day as an intern. George catches on and says it felt really good.

Alex and Cristina are sitting and Alex tells her he misses Ava, she tells him she misses Burk.

Meredith and Derek are talking, he says so we are really over aren’t we, she says yes ”OVER”. He goes in to kiss her but she pulls away a little until they finally begin kissing. She says “break up kiss” He says yes “break up kiss” they start undressing and they say “Break up sex”….Yes….

Izzie goes to her door to find George and he finally tells her He Loves her.

Next week on Grey’s Anatomy:

“Love/Addiction”

The residents and interns treat the victims of a massive explosion at an apartment building, while Alex investigates the cause of the accident, Mama Burke returns to collect her son’s things just as Cristina trades her wedding presents in exchange for surgeries, Lexie tries to have a heart-to-heart with an unwilling Meredith, and while Callie is overwhelmed with her duties as Chief Resident, Bailey searches for an outlet for her pent-up leadership skills.